Perceived social support and quality of life among persons with bipolar affective disorders and alcohol dependence: A comparative study

Background: Bipolar affective disorders (BPAD) and Alcohol dependence syndrome (ADS) are globally found in the general population. These disorders are characterized by similar dysfunction in families like inadequate support system and poor quality of life. Aim: This study aims to explore the perceived social support and quality of life of the person diagnosed with BPAD and ADS (ICD- 10 DCR) and find out its relationship with socio-demographic variables. Methods: This research study was done at the inpatient and outpatient department of Ranchi Institute of Neuropsychiatry and Allied Sciences (RINPAS), Kanke, Ranchi and data was collected by the purposive sampling technique from RINPAS, Ranchi. The sample consisted of 60 subjects, equally divided BPAD and ADS (subjects diagnosed as per ICD- 10 DCR). A Socio-demographical Data-sheet, Multidimensional Perceived Social Support (MSPPS) and Quality of life scales were used in the study. Result: The result shows that the mean age of the participants was 30.36±6.84 years for BPAD and 32.40±5.73 years for ADS. Also, the study found that participants of ADS had poor quality of life (p<.001). Conclusion: The study indicates that the severity of Alcohol dependence syndrome affects individual quality of life. The study found that perceived social support is also affected similarly in both the disorders BPAD and ADS.   Keywords: Bipolar affective disorder, alcohol dependence syndrome, perceived social suppor

AMLEORATIVE ROLE OF ESCULETIN􀇧MEDIATED RENOPROTECTION AGAINST GENTAMICIN􀇧INDUCED NEPHROTOXICITY AND POSSIBLE INVOLVEMENT OF N􀇧METHYL􀇧D􀇧ASPARTATE RECEPTORS

Objective: In this investigation, the amleorative role of esculetin (Esc) was investigated in gentamicin (Genta) nephrotoxicity in rats and the possible role of N-methyl-D-aspartate receptors (NMDAR) in genta-induced nephrotoxicity.Methods: Genta (100 mg/kg/day, i.p. for 7 days) was administered to rats for the induction of nephrotoxicity, and subsequently, the extent of renal damage was measured by estimating creatinine clearance (CrCl), blood urea nitrogen (BUN), uric acid, microprotienuria and fractional excretion of sodium, and potassium. In addition, renal superoxide anion generation (SAG), Thiobarbituric acid reactive substance (TBARS), and reduced glutathione (GSH) level were used to evaluate renal oxidative parameters. Renal myeloperoxidase (MPO) activity was used to measure renal inflammation. D-serine, NMDA agonist was used in this study to evaluate the role of NMDA antagonist in genta-induced nephrotoxicity. Histopathological examination was performed using hematoxylin and eosin staining method.Results: Genta-treated rats exhibited remarkable changes in renal parameters like increase in BUN, uric acid, microprotein fractional excretion of sodium and potassium with decrease in CrCl and similarly biochemical parameters like increase in SAG, thiobarbituric acid reactive species (TBARS), MPO activity with decrease in GSH level. Treatment with Esc (5 and 10 mg/kg/day, i.p for 7 days), NMDAR antagonist attenuated the genta-induced nephrotoxicity but did not shown significant effect on combined use of genta and D-serine treated group. Histopathological examination of gentatreated rats. The coadministration of Esc + genta-protected kidney tissue from nephrotoxic effect of genta as illustrated by normalization of tubules but not with the combined use of Esc + genta + D-serine treated rats.Conclusion: Esc displayed protective effect in genta-induced nephrotoxicity but combined effect of Esc + genta + D-serine abolished the protective effect of Esc thus confirming that NMDAR may be involved in genta-induced nephrotoxicity

Enhancing Feature Selection Accuracy using Butterfly and Lion Optimization Algorithm with Specific Reference to Psychiatric Disorder Detection & Diagnosis

As the complexity of medical computing increases the use of intelligent methods based on methods of soft computing also increases. During current decade this intelligent computing involves various meta-heuristic algorithms for Optimization. Many new meta-heuristic algorithms are proposed in last few years. The dimension of this data has also wide. Feature selection processes play an important role in these types of wide data. In intelligent computation feature selection is important phase after the pre-processing phase. The success of any model depends on how better optimization algorithms is used. Sometime single optimization algorithms are not enough in order to produce better result. In this paper meta-heuristic algorithm like butterfly optimization algorithm and enhanced lion optimization algorithm are used to show better accuracy in feature selection. The study focuses on nature based integrated meta-heuristic algorithm like Butterfly Optimization and lion-based optimization. Also, in this paper various other Optimization algorithms are analyzed. The study shows how integrated methods are useful to enhance the accuracy of any computing model to solve Complex problems. Here experimental result has shown by proposing and hybrid model for two major psychiatric disorders one is known as autism spectrum and second one is Parkinson's disease

Improving Accuracy of Integrated Neuro-Fuzzy Classifier with FCM based Clustering for Diagnosis of Psychiatric Disorder

Parkinson’s disease (PD) is a progressive neurodegenerative disorder. Autism spectrum disorder (ASD) is a neurodevelopment disorder. Clinical decision-making process is complex. Due to complex nature of disease sign and its symptoms clinical decision making may lead to misclassification. To deal with such complex medical problems methods or approaches of soft computing play an important role. This paper will focus on presenting an integrated Neuro-fuzzy model. This integrated model has the learning strength of neural network and knowledge representation ability of fuzzy logic. Modified Adaptive Neuro –Fuzzy inference system (M-ANFIS) is used here for classification and predication. Here Fuzzy C-mean (FCM) Clustering is used first to make classes of data before presenting in to ANFIS. This FCM based class will reduce the classifier computational overhead. Precision error and recall, F-measure and accuracy matrices are used to compare the experimental results with other classic methods

Erenumab aooe: a milestone for the preventive treatment of migraine

Migraine is a complex neurological condition, which can affect the whole body and can result in many symptoms as nausea, vomiting, photophobia (Increased sensitivity to light), phonobhobia (Increased sensitivity to sound) and osmophobia (Increased sensitivity to smell). Neurological symptoms that include visual disturbances such as blind spots, distorted vision, flashing lights or zigzag patterns. Other common symptoms includes- dizziness, vertigo, tingling sensations in the limbs, an inability to concentrate, confusion, difficulty in speaking, paralysis or loss of consciousness (in very rare cases). These symptoms, often called ‘aura’. Migraine attacks may differ in their frequency, duration and severity, although, normally they last between 4 and 72 hours, and most people are symptom-free between attacks. There are many drugs for the treatment of acute attack of migraine which can be divided into mild, moderate and severe attacks. In mild case NSAIDs like Paracetamol, Ibuprofen are prescribed. In moderate cases Anti-emetics like metoclopramide, domperidone can be prescribe with combinations of NSAIDs or triptans as sumatriptan. In case of severe cases triptans can be prescribed with ergot alkaloids and antiemetics. Following drugs are prescribed for the prophylaxis of migraine as sodium valproate, amitriptyline (Tricyclic antidepressant), propranolol and metoprolol (beta blockers). Erenumab-aooe is a calcitonin gene-related peptide receptor antagonist. It is specifically indicated for the preventative treatment of migraine in adults. Erenumab-aooe is supplied as an injection for subcutaneous use. The recommended dosage is 70 mg injected subcutaneously once monthly. Some patients may benefit from a dosage of 140 mg injected subcutaneously once monthly, which is administered as two consecutive subcutaneous injections of 70 mg each. Erenumab-aooe is a human monoclonal antibody that binds to the calcitonin gene-related peptide (CGRP) receptor and antagonizes CGRP receptor function

Study of self drug administration among second professional medical students

Background: Self-medication is very common in our day to day life which is an unhealthy and risky practice. Present study was done to determine the knowledge, attitude and practice among second professional medical students.Methods: A questionnaire related to self-medication with consent was prepared and distributed among the students of second professional. Data was collected and analysed the results expressed as counts and percentages.Results: Total 100 students participated in the study for taking self-medication and was no need to visit the doctor for minor illness. In maximum students, source of information of the drugs used for self-medication pharmacological based and learning process in the college. The source of drug was medical store. Most of the students took self-medication for loose motion and headache followed by cough, cold and fever. Out of total 100 students most of the students took paracetamol tablet as self-medication.Conclusions: This study showed that second professional medical students after studying pharmacological books they do not use any wrong medicine as self-medication. High level of awareness of second professional students has minimized self medication

Roles of the troponin isoforms during indirect flight muscle development in Drosophila

Troponin proteins in cooperative interaction with tropomyosin are responsible for controlling the contraction of the striated muscles in response to changes in the intracellular calcium concentration. Contractility of the muscle is determined by the constituent protein isoforms, and the isoforms can switch over from one form to another depending on physiological demands and pathological conditions. In Drosophila, amajority of themyofibrillar proteins in the Indirect Flight Muscles (IFMs) undergo post-transcriptional and post-translational isoform changes during pupal to adult metamorphosis to meet the high energy and mechanical demands of flight. Using a newly generated Gal4 strain (UH3-Gal4) which is expressed exclusively in the IFMs, during later stages of development, we have looked at the developmental and functional importance of each of the troponin subunits (troponin-I, troponin-T and troponin-C) and their isoforms. We show that all the troponin subunits are required for normal myofibril assembly and flight, except for the troponin-C isoform 1 (TnC1). Moreover, rescue experiments conducted with troponin-I embryonic isoform in the IFMs, where flies were rendered flightless, show developmental and functional differences of TnI isoforms and importance of maintaining the right isoform

Structural, Dielectric and Electrical Properties of Homovalent Doped SrSn1-xTixO3 (0 ≤ x ≤ 0.08) System

The samples SrSn1-xTixO3 with composition 0≤x≤0.08 have been prepared using sol-gel chemical route by sintering at 1173 K. All the samples are found to be single phase crystallized in orthorhombic structure. The dielectric properties indicate the existence of interfacial and orientation polarization in samples found to be stable up to 300 oC. Thermal dependence of electrical conductivity represents two conduction regions with activation energy (0.77-0.94) eV in region-1 and (0.19-0.27) eV in region-2 respectively. The plot of dc conductivity with hopping frequency results unit slope representing that the charge carriers remain same in both processes. DC conductivity of samples are found to be increased with Ti4+, due to reduction in polaron size. The present materials can be potentially used in thermally stable capacitor and mixed ionic and electronic conductors (MIECs) applications

HUBUNGAN ANTARA PENGETAHUAN DAN SIKAP IBU TENTANG ASI EKSKLUSIF DENGAN PEMBERIAN ASI EKSKLUSIF PADA BAYI DI GAMPONG LAMGUGOB KECAMATAN SYIAH KUALA BANDA ACEH TAHUN 2012

KEMENTRIAN PENDIDIKAN NASIONALUNIVERSITAS SYIAH KUALAFAKULTAS KEDOKTERANPROGRAM STUDI ILMU KEPERAWATANSKRIPSIxiv Halaman + VI Bab + 67 Halaman + 8 Tabel + 1 Skema + 16 LampiranERI MAULIDAR1007101190027HUBUNGAN ANTARA PENGETAHUAN DAN SIKAP IBU TENTANG ASI EKSKLUSIF DENGAN PEMBERIAN ASI EKSKLUSIF PADA BAYI DI GAMPONG LAMGUGOB KECAMATAN SYIAH KUALA BANDA ACEH TAHUN 2012ABSTRAKPemberian air susu ibu (ASI) eksklusif, belum begitu populer di masyarakat Banda Aceh. Bahkan, banyak ibu melahirkan belum mengetahui pentingnya pemberian ASI eksklusif kepada bayi yang baru dilahirkan. Rendahnya pemahaman masyarakat terkait ASI eksklusif, karena pengaruh mitos yang sudah berkembang secara turun-temurun, menyebabkan tidak berhasilnya pemberian ASI eksklusif. Penelitian ini bertujuan untuk mengetahui hubungan antara pengetahuan ibu tentang ASI eksklusif dengan pemberian ASI eksklusif pada bayi, dan hubungan antara sikap ibu tentang ASI eksklusif dengan pemberian ASI ekeklusif pada bayi di Gampong Lamgugob Kecamatan Syiah Kuala Banda Aceh Tahun 2012. Desain penelitian bersifat deskriptif korelatif dan teknik pengambilan sampel menggunakan total sampling yaitu 52 responden. Instrumen penelitian berupa kuesioner dengan teknik wawancara terpimpin, waktu penelitian dilakukan 10-14 Oktober 2012, metode analisis data menggunakan uji chi-square. Hasil univariat menunjukkan (50%) responden, berada pada katagori pengetahuan tinggi, (52%) responden menunjukkan sikap baik, (29%) responden berada pada katagori eksklusif dalam memberikan ASI eksklusif pada bayi di Gampong Lamgugob Kecamatan Syiah Kuala Banda Aceh. Hasil analisis bivariat di dapatkan tidak ada hubungan antara pengetahuan ibu tentang ASI eksklusif dengan pemberian ASI eksklusif pada bayi (p-value 0,066), ada hubungan antara sikap ibu tentang ASI eksklusif dengan pemberian ASI eksklusif pada bayi (p-value 0,004) di Gampong Lamgugob Kecamatan Syiah Kuala Banda Aceh. Diharapkan kepada ibu untuk lebih dapat meningkatkan pengetahuan mengenai pemberian ASI eksklusif dan sikap yang positif terhadap ASI eksklusif sehingga program pemberian ASI eksklusif pada bayi berhasil dilakukan.Kata Kunci : pengetahuan, sikap, ASI eksklusifDaftar bacaan : 23 buku, 10 internet (2002-2012)Banda Ace

Protecting Scattered Database by Enforcing Data Preservation Using Data Protection Facilitator

In this paper we are incorporating data preservation in scattered database structure i.e. method of preserving data in scattered database structure and having secure access over it. In this paper data preservation is examined and solution is provided on the aforesaid condition. This paper is a summarized concept of documentation, authorization, access control and encryption that are main points to be taken in consideration in data preservation in scattered database structure. We propose a new method for secure access based on service provider comprising security application. This model set out for safe search on server and user relation. In this paper we used heuristic approach for preservation for scattered database system regarding security, as the importance of secure access is increasing in scattered domains on different issues, in this way we enhanced the database security in Scattered database environment